Respiratory disturbance index as a predictor of atrial fibrillation

Abstract Background Obstructive sleep apnea (OSA) is a risk factor for development of atrial fibrillation (AF). Recent pacemakers have specific algorithms detecting OSA based on impedance measurement. Purpose The aim was to determine the burden AF in patients with high respiratory disturbance index (RDI). It also intended if onset continuous positive airway pressure (CPAP) reduced burden. Methods Retrospective observational study carried out through analysis patient records. included evaluated an outpatient clinic during first 8 months 2018. All had RDI algorithm. assessed according automatic mode switch (AMS) duration. percentage nights RDI>20/h analysed assess OSA. Results 108 were (mean age=70.3±9.0 years; 56.5% men). most prevalent indication cardiac pacing atrioventricular node dysfunction (59.3%). average 44.2%. follow-up (FU) period 4.1 years. Of all cardiovascular factors, diabetes mellitus only one associated higher incidence at FU (p=0.044). Considering just >20/h more than 20% (RDI20%), male gender rate major adverse events [(acute myocardial infarction, stroke, acute heart failure and death) (p=0.019)]. prior pacemaker implantation (n=34), 76% 58.1%). 23 these long standing persistent end (vs 17 beginnig FU). who developed after (n=24), 58% 45.3%). Most paroxismal (83%). Patients paroxysmal or those (n=37) when they 50% 24.66% vs 14.69%, p=0.005). There no statistically significant correlation between Apnea Hypopnea Index (AHI) value. underwent polysomnography (n=30) mean AHI 16/h (which corresponds moderately severe OSA). 63% referred from consultation pneumology performed started CPAP. CPAP use not reduction any endpoints Conclusion A de novo AF. Thus, there rationale early diagnosis treatment OSAS prevent reduce progression. In this study, shown significantly endpoint, probably due treatment. Funding Acknowledgement Type funding sources: None.